Intercalate or invaginate: PI(3,4,5)P3 governs a membrane constriction switch in cell shaping.

Although contractile processes, from tissue invagination to cell intercalation, utilize diverse ratcheting mechanisms, little is known about how ratcheting becomes engaged at specific cell surfaces. In this issue of Developmental Cell, Maio et al. demonstrate that PI(3,4,5)P3 is a paramount regulator of the Sbf/RabGEF-Rab35 ratchet mechanism.Copyright © 2021. Published by Elsevier Inc.

Citation

Gabriel Baonza, Gonzalo Herranz, Fernando Martin-Belmonte. Intercalate or invaginate: PI(3,4,5)P3 governs a membrane constriction switch in cell shaping. Developmental cell. 2021 Sep 27;56(18):2542-2544

PMID: 34582770

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