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The study explored the cross-talk between the microRNA miR-34a and prominin 1 in the development of laryngeal cancer (LC), which has an unacceptable high mortality rate. We predicted that miR-34a might target prominin 1. miR-34a and prominin 1 expression was analyzed with reverse transcription quantitative polymerase chain reaction. The correlation between miR-34a and prominin 1 was determined by linear regression analysis. miR-34a and prominin 1 overexpression and miR-34a inhibition were achieved in LC cells to analyze their relationship. The roles of miR-34a and prominin 1 in LC cell proliferation were studied with CCK-8 assay. The results showed miR-34a was downregulated, and prominin 1 was upregulated in LC. In addition, prominin 1 and miR-34a were inversely correlated across cancer tissue samples. In cancer cells, miR-34a overexpression downregulated prominin 1, while miR-34a knockdown upregulated prominin 1. Moreover, miR-34a overexpression reduced the enchaining effects of prominin 1 on LC cell proliferation. Therefore, miR-34a might suppress LC cell proliferation by targeting prominin 1.


Xianyang Luo, Aimin Chen, Yi Zhou, Binghuang Zhang, Yuanqin Jiang, Zhizong Hong. miR-34a Suppresses Cell Proliferation in Laryngeal Cancer by Targeting Prominin 1. Critical reviews in eukaryotic gene expression. 2021;31(5):51-57

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PMID: 34591390

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