Cyclization and Self-Assembly of Cyclic Peptides.

Alejandro Méndez-Ardoy, Ignacio Insua, Juan R Granja, Javier Montenegro

Methods in molecular biology (Clifton, N.J.) 2022

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Cyclic peptides are a fascinating class of molecules that can be programmed to fold or self-assemble into diverse mono- and multidimensional structures with potential applications in biomedicine, nanoelectronics, or catalysis. Herein we describe on-resin procedures to carry out head-to-tail peptide cyclization based on orthogonal protected linear structures. We also present essential characterization tools for obtaining dynamic and structural information, including the visualization cyclic peptide assembly into nanotubes (AFM, TEM) as well as the use of fluorescence microscopy. © 2022. Springer Science+Business Media, LLC, part of Springer Nature.

Citation

Alejandro Méndez-Ardoy, Ignacio Insua, Juan R Granja, Javier Montenegro. Cyclization and Self-Assembly of Cyclic Peptides. Methods in molecular biology (Clifton, N.J.). 2022;2371:449-466