Correlation Engine 2.0
Clear Search sequence regions

  • cancer (7)
  • cancer stem cells (1)
  • cellular (1)
  • fibroblasts (1)
  • homeostasis (1)
  • humans (1)
  • JAK (1)
  • signal (2)
  • TGF- β (13)
  • Sizes of these terms reflect their relevance to your search.

    Transforming growth factor beta (TGF-β) plays key roles in regulating cellular proliferation and maintaining tissue homeostasis. TGF-β exerts tumor-suppressive effects in the early stages of carcinogenesis, but it also plays tumor-promoting roles in established tumors. Additionally, it plays a critical role in cancer radiotherapy. TGF-β expression or activation increases in irradiated tissues, and studies have shown that TGF-β plays dual roles in cancer radiosensitivity and is involved in ionizing radiation-induced fibrosis in different tumor microenvironments (TMEs). Furthermore, TGF-β promotes radioresistance by inducing the epithelial-mesenchymal transition (EMT), cancer stem cells (CSCs) and cancer-associated fibroblasts (CAFs), suppresses the immune system and facilitates cancer resistance. In particular, the links between TGF-β and the Janus kinase (JAK)/signal transducer and activator of transcription (STAT) axis play a critical role in cancer therapeutic resistance. Growing evidence has shown that TGF-β acts as a radiation protection agent, leading to heightened interest in using TGF-β as a therapeutic target. The future of anti-TGF-β signaling therapy for numerous diseases appears bright, and the outlook for the use of TGF-β inhibitors in cancer radiotherapy as TME-targeting agents is promising. Copyright © 2021 Elsevier Ltd. All rights reserved.


    Juan Wang, Zhonghang Xu, Zhe Wang, Guoqiang Du, Limin Lun. TGF-beta signaling in cancer radiotherapy. Cytokine. 2021 Dec;148:155709

    Expand section icon Mesh Tags

    Expand section icon Substances

    PMID: 34597918

    View Full Text