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    The liver increases its size during pregnancy to adapt to metabolic demand associated with pregnancy. Our previous study showed that proliferation of maternal hepatocytes are increased during pregnancy in mice and that estradiol (E2) is one of the candidate hormones responsible for maternal hepatocyte proliferation. Here, we discovered that chorionic gonadotropin (CG) induces maternal hepatocyte proliferation during pregnancy. CG administration was sufficient to stimulate hepatocyte proliferation in non-pregnant mice as well as in cell culture system. We conclude that CG stimulates proliferation in the early pregnancy of maternal hepatocytes. In contrast, estrogen stimulates hepatocyte proliferation in the late pregnancy. Copyright © 2021 Elsevier Inc. All rights reserved.


    Jaeyong Cho, Yoji Tsugawa, Yumi Imai, Takeshi Imai. Chorionic gonadotropin stimulates maternal hepatocyte proliferation during pregnancy. Biochemical and biophysical research communications. 2021 Nov 19;579:110-115

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    PMID: 34597993

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