The Level and Significance of Circulating Angiotensin-III in Patients with Coronary Atherosclerosis.

Angiotensin-III (Ang-III) is the downstream product of angiotensin-II (Ang-II) metabolized by aminopeptidase A (APA). At present, the research of Ang-III mainly concentrates on hypertension and the central renin-angiotensin system (RAS). However, few studies have focused on the relationship between Ang-III and coronary atherosclerosis (CAS). Plasma Ang-III and APA levels were measured by the enzyme-linked immunosorbent assay (ELISA) in 44 normal subjects and 84 patients confirmed as having CAS by coronary angiography. Circulating Ang-III levels were significantly lower in patients with CAS than in normal controls (P = 0.013). APA levels were slightly lower in the CAS group (P = 0.324). According to the severity of atherosclerosis, CAS patients were divided into two groups. Compared with the controls, the APA and Ang-III levels were lower in the high scoring group and APA decreased significantly. Circulating Ang-III levels were reduced in patients with CAS, and the possible reason may be related to the decrease in the APA level. Copyright © 2021 Guoqing Yao et al.

Citation

Guoqing Yao, Wenjing Li, Wenzhao Liu, Jingbo Xing, Cheng Zhang. The Level and Significance of Circulating Angiotensin-III in Patients with Coronary Atherosclerosis. Journal of the renin-angiotensin-aldosterone system : JRAAS. 2021;2021:1704762

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PMID: 34603502

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