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Cancer treatment related injury to the central nervous system (CNS) is well-recognized in the setting of brain-directed radiation therapies and conventional and novel systemic anticancer therapies. Late-delayed treatment-induced CNS complications frequently result in permanent neurologic disability. Therapeutic options are supportive with limited clinical benefit, whereby alteration or discontinuation of the overall antineoplastic treatment plan is frequently necessary to prevent further neurologic injury. Better identification of patients at high risk for developing late CNS toxicities, neuroprotective strategies with modification of existing antineoplastic treatment regimens, and research efforts directed at earlier recognition and improved treatment of central neurologic complications are paramount. Copyright © 2021 Elsevier Inc. All rights reserved.


Sebastian F Winter, Jasmin Jo, David Schiff, Jorg Dietrich. Central Nervous System Complications Among Oncology Patients. Hematology/oncology clinics of North America. 2022 Feb;36(1):217-236

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PMID: 34607715

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