Transferrin receptors/magnetic resonance dual-targeted nanoplatform for precise chemo-photodynamic synergistic cancer therapy.

Pingyun Ge, Yuqing Liu, Qing Chen, Zaiji Su, Yuting Du, Shuting Luo, Xuemei Zhao, Xiufeng Cao, Hua Song, Xuan Zhu

Nanomedicine : nanotechnology, biology, and medicine 2022 Jan

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Various drug delivery strategies to improve cancer therapeutic efficacy have been actively investigated. One major challenge is to improve the targeting ability. Here elaborately designed nanocarriers (NCs) named as Tf-5-ALA-PTX-NCs are demonstrated to address this problem. In this nanostructure, paclitaxel (PTX) and 5-aminolevulinic acid (5-ALA) were co-encapsulated within magnetic nanocarriers to achieve synergistic chemotherapy and photodynamic therapy, while transferrin (Tf) was conjugated with modified copolymer Pluronic P123 and embedded in the surface of the nanocarriers, which endows nanocarriers with Tf targeting and magnetic targeting to enhance the anti-tumor outcome. Results demonstrated that Tf-5-ALA-PTX-NCs significantly enhanced the targeting drug delivery to MCF-7 cells and synergistically induced apoptosis and death of MCF-7 cells in vitro and highly efficient tumor ablation in vivo. Intriguingly, Tf-5-ALA-PTX-NCs have a controllable "on/off" switch to enhance the drug release. The dual-targeted nanocarriers would be a promising versatile anti-tumor drug delivery and imaging-guided cancer chemo-photodynamic synchronization therapy strategy. Copyright © 2021 Elsevier Inc. All rights reserved.

Citation

Pingyun Ge, Yuqing Liu, Qing Chen, Zaiji Su, Yuting Du, Shuting Luo, Xuemei Zhao, Xiufeng Cao, Hua Song, Xuan Zhu. Transferrin receptors/magnetic resonance dual-targeted nanoplatform for precise chemo-photodynamic synergistic cancer therapy. Nanomedicine : nanotechnology, biology, and medicine. 2022 Jan;39:102467