Biologically active lipids in the regulation of lymphangiogenesis in disease states.

Masataka Majima, Kanako Hosono, Yoshiya Ito, Hideki Amano

Pharmacology & therapeutics 2022 Apr

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Lymphatic vessels have crucial roles in the regulation of interstitial fluids, immune surveillance, and the absorption of dietary fat in the intestine. Lymphatic function is also closely related to the pathogenesis of various disease states such as inflammation, lymphedema, endometriosis, liver dysfunction, and tumor metastasis. Lymphangiogenesis, the formation of new lymphatic vessels from pre-existing lymphatic vessels, is a critical determinant in the above conditions. Although the effect of growth factors on lymphangiogenesis is well-characterized, and biologically active lipids are known to affect smooth muscle contractility and vasoaction, there is accumulating evidence that biologically active lipids are also important inducers of growth factors and cytokines that regulate lymphangiogenesis. This review discusses recent advances in our understanding of biologically active lipids, including arachidonic acid metabolites, sphingosine 1-phosphate, and lysophosphatidic acid, as regulators of lymphangiogenesis, and the emerging importance of the lymphangiogenesis as a therapeutic target. Copyright © 2021 The Authors. Published by Elsevier Inc. All rights reserved.

Citation

Masataka Majima, Kanako Hosono, Yoshiya Ito, Hideki Amano. Biologically active lipids in the regulation of lymphangiogenesis in disease states. Pharmacology & therapeutics. 2022 Apr;232:108011