Deciphering the modes of human separase inhibition by securin and CDK1-CCNB1.

Accurate chromosome segregation depends on tight regulation of the protease separase, which cleaves the ring-shaped cohesin complex that entraps the two sister chromatids. We recently reported structures of human separase bound to its inhibitors securin or the cyclin-dependent kinase 1 (CDK1)-cyclin B1 (CCNB1)-cyclin-dependent kinases regulatory subunit 1 (CKS1) complex and discovered an array of molecular mechanisms that block cohesin-cleavage. © 2021 Taylor & Francis Group, LLC.

Citation

Pierre Raia, Jun Yu, Andreas Boland. Deciphering the modes of human separase inhibition by securin and CDK1-CCNB1. Molecular & cellular oncology. 2021;8(4):1975473

PMID: 34616878

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