The association between serum level and genetic variation of IL-3 (rs40401) in recurrent abortion women infected with toxoplasmosis in Iraq.

Noor Nihad Baqer, Najwa Shihab Ahmed, Entsar Jabbar Saheb

Cytokine 2022 Jan

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Toxoplasmosis is one of the most infections during pregnancy transmitted from mother to child via the placenta and causes morbidity and mortality prenatally. IL-3 is a hematopoiesis enhancing factor and assist in the implantation embryo and placental growth. The objective of this study is to provide valuable information about the risks of IL-3 elevated levels in aborted women with toxoplasmosis by determining the risk, or the protective role of alleles or genotypes for single nucleotide polymorphism (SNP) of IL-3 (rs40401) which might have a relationship with the susceptibility to toxoplasmosis. The levels of IL-3 in blood samples of patients and controls were detected by ELISA while the allelic discrimination method was used for SNP IL-3 (rs40401). The results suggested the IL-3 serum concentration of healthy pregnant women(HP), recurrent abortion women without toxoplasmosis (RAWOT), and recurrent abortion women with toxoplasmosis(RAWT) was declined versus healthy non pregnant women (HNP) with a statistically significant difference (p < 0.05). Moreover, the results SNP of IL-3 showed no significant association between patients and controls. Considering the distribution of serum levels for IL-3 by SNPs, the results have shown the serum level of IL-3 for the genotype CC, CT, TT in RAWOT and RAWT declined comparing to HNP women with significant differences (p < 0.05). In conclusion, SNP of IL-3 has not represented as a risk factor in recurrent abortion women with toxoplasmosis. Although the serum levels of IL-3 differed in patients according to genotype with significant differences compared to control. Copyright © 2021 Elsevier Ltd. All rights reserved.

Citation

Noor Nihad Baqer, Najwa Shihab Ahmed, Entsar Jabbar Saheb. The association between serum level and genetic variation of IL-3 (rs40401) in recurrent abortion women infected with toxoplasmosis in Iraq. Cytokine. 2022 Jan;149:155718