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    The endophytic fungus Diaporthe sp. is known to contain many secondary metabolites, but fatty acid derivatives have rarely been found. In this study, four new fatty acid derivatives (1-4), together with four known compounds (5-8), were isolated from Diaporthe sp., which was obtained from the stem of Ligularia fischeri. The absolute configurations of the new compounds 1-4 were deduced based on spectroscopic technique and J-based coupling constant analysis. Moreover, compound 1 exhibited cytotoxic activities against HCT-8 and MCF-7 cancer cells, and compounds 3 and 4 showed modest selectivity for HCT-8 cells by MTT assay.

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    Min He, Wan-Qiang Yin, Hai-Feng Sun, Yu-Wei Ding, Shuai Xu, Hua Sun, Jia-Ming Wang, Peng Yu, Hai-Juan Qin, Ming-Hua Chen. Four new fatty acid derivatives from Diaporthe sp. T24, an endophytic fungus isolated from Ligularia fischer. Journal of Asian natural products research. 2022 Jul;24(7):603-616

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    PMID: 34622714

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