Chain release mechanisms in polyketide and non-ribosomal peptide biosynthesis.

Rory F Little, Christian Hertweck

Natural product reports 2022 Jan 26

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Review covering up to mid-2021The structure of polyketide and non-ribosomal peptide natural products is strongly influenced by how they are released from their biosynthetic enzymes. As such, Nature has evolved a diverse range of release mechanisms, leading to the formation of bioactive chemical scaffolds such as lactones, lactams, diketopiperazines, and tetronates. Here, we review the enzymes and mechanisms used for chain release in polyketide and non-ribosomal peptide biosynthesis, how these mechanisms affect natural product structure, and how they could be utilised to introduce structural diversity into the products of engineered biosynthetic pathways.

Citation

Rory F Little, Christian Hertweck. Chain release mechanisms in polyketide and non-ribosomal peptide biosynthesis. Natural product reports. 2022 Jan 26;39(1):163-205