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Copper-Catalyzed Direct Cycloaddition of Imidazoles and Alkenes to Trifluoromethylated Tricyclic Imidazoles.
The Journal of organic chemistry 2021 Nov 05Sizes of these terms reflect their relevance to your search.
We reported herein a copper-catalyzed trifluoromethylarylated cycloaddition of imidazoles and olefins using CF3SO2Cl as the radical source to synthesize highly functionalized tricyclic imidazoles. This procedure exhibits a wide range of substrate scope with 25%-93% isolated yields (36 examples). Mechanistic studies were carried out to support a free trifluoromethyl radical pathway.
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Shengnan Lin, Jianchao Cui, Yu Chen, Yi Li. Copper-Catalyzed Direct Cycloaddition of Imidazoles and Alkenes to Trifluoromethylated Tricyclic Imidazoles. The Journal of organic chemistry. 2021 Nov 05;86(21):15768-15776
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PMID: 34632765
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