The Ryanodine Receptor as a Sensor for Intracellular Environments in Muscles.

Takuya Kobayashi, Nagomi Kurebayashi, Takashi Murayama

International journal of molecular sciences 2021 Oct 06

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The ryanodine receptor (RyR) is a Ca2+ release channel in the sarcoplasmic reticulum of skeletal and cardiac muscles and plays a key role in excitation-contraction coupling. The activity of the RyR is regulated by the changes in the level of many intracellular factors, such as divalent cations (Ca2+ and Mg2+), nucleotides, associated proteins, and reactive oxygen species. Since these intracellular factors change depending on the condition of the muscle, e.g., exercise, fatigue, or disease states, the RyR channel activity will be altered accordingly. In this review, we describe how the RyR channel is regulated under various conditions and discuss the possibility that the RyR acts as a sensor for changes in the intracellular environments in muscles.

Citation

Takuya Kobayashi, Nagomi Kurebayashi, Takashi Murayama. The Ryanodine Receptor as a Sensor for Intracellular Environments in Muscles. International journal of molecular sciences. 2021 Oct 06;22(19)