Emerging role of let-7 family in the pathogenesis of hematological malignancies.

Fatemeh Yazarlou, Sepideh Kadkhoda, Soudeh Ghafouri-Fard

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2021 Dec

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Let-7 includes a family of miRNA which are implicated in the developmental processes as well as carcinogenesis. This miRNA family has been shown to influence pathogenesis of a variety of hematological malignancies through changing expression of a number of oncogenic pathways, particularly those related with MYC. Expression of these miRNAs has been found to be different between distinct hematological malignancies or even between cytogenetically-defined subgroups of a certain malignancy. In the current review, we summarize the data regarding biogenesis, genomic locations, targets and regulatory network of this miRNA family in the context of hematological malignancies. Copyright © 2021 The Authors. Published by Elsevier Masson SAS.. All rights reserved.

Citation

Fatemeh Yazarlou, Sepideh Kadkhoda, Soudeh Ghafouri-Fard. Emerging role of let-7 family in the pathogenesis of hematological malignancies. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2021 Dec;144:112334