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Nine new dolabrane-type diterpenoids, notoscarins A-I (1-9), including an unprecedented 6,18-cyclo-dolabrane-type diterpenoid (1) obtained through intramolecular cyclization, two rare 19-nor-2-chloro-dolabrane diterpenoids (2 and 3), six new related dolabrane-type diterpenoids (4-9), and one new butyrolactone derivative (10), were isolated from the Chinese liverwort Notoscyphus lutescens. The 6,18-cyclo-dolabrane and 19-nor-dolabrane carbon skeletons are reported for the first time. The structures of these compounds were determined on the basis of MS and NMR spectroscopic data, single-crystal X-ray diffraction, and electronic circular dichroism calculations. Preliminary bioassays showed that compounds 1-10 exhibited moderate to weak quinone reductase-inducing activity in Hepa-1c1c7 cells.


Jingjing Han, Yi Li, Jinchuan Zhou, Xinyu Qi, Hui Meng, Jiaozhen Zhang, Yan Sun, Yanan Qiao, Bin Sun, Hongxiang Lou. Dolabrane Diterpenoids from the Chinese Liverwort Notoscyphus lutescens. Journal of natural products. 2021 Nov 26;84(11):2929-2936

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PMID: 34662124

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