Correlation Engine 2.0
Clear Search sequence regions

  • CS 1 (1)
  • diesel exhaust (11)
  • DPPC (7)
  • hydrocarbons (3)
  • lung (1)
  • Sizes of these terms reflect their relevance to your search.

    Long term exposure to diesel exhaust particulate matter (DEPM) can induce numerous adverse health effects to the respiratory system. Understanding the interaction between DEPM and pulmonary surfactant (PS) can be an essential step toward preliminary evaluation of the impact of DEPM on pulmonary health. Herein, DEPM was explored for its interaction with 1,2-dipalmitoyl-sn-glycerol-3-phosphocholine (DPPC), the major component of PS. The results indicated that the surface pressure-area (π-A) isotherms of DPPC monolayers shifted toward lower molecular areas and the compression modulus (CS-1) reduced in the presence of DEPM. Atomic force microscopy image showed that DEPM can disrupt the ultrastructure of DPPC monolayers along with the direction of lateral compression. In addition, DPPC can in turn condition the surface properties of DEPM, permitting its agglomeration in aqueous media, which was attributed to the adsorption of DEPM to DPPC. Furthermore, the particle-bound polycyclic aromatic hydrocarbons (PAHs) could be desorbed from DEPM by the solubilization of DPPC and it was positively correlated with the hydrophobicity of PAHs. These findings revealed the toxicity of DEPM-associated PAHs and the role of DPPC in facilitating the removal of the inhaled particles, which can provide a new insight into the potential hazards of airborne particles on lung health. Copyright © 2021 Elsevier B.V. All rights reserved.


    Yingxue Geng, Yan Cao, Qun Zhao, Yingjie Li, Senlin Tian. Potential hazards associated with interactions between diesel exhaust particulate matter and pulmonary surfactant. The Science of the total environment. 2022 Feb 10;807(Pt 3):151031

    Expand section icon Mesh Tags

    Expand section icon Substances

    PMID: 34666082

    View Full Text