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Rhabdoid tumors (RTs) are a rare and aggressive pediatric cancer that commonly presents with alterations in the tumor suppressor gene SMARCB1. However, RT prognosis is still poor, with no standard treatment available. Moreover, no predictive biomarkers have been identified for determining its aggressiveness or chemo- and radio-sensitivities. Herein, four cases of extra-cranial RTs (ERTs) are described, two of whom are long-term survivors. These two surviving patients were positive for p16, whereas the other two were p16-negative. Our findings suggest that biologically distinct types of ERTs exist and that p16 expression may be a potential positive prognostic biomarker of ERTs. Nevertheless, further studies are required to confirm our findings.

Citation

Yoshiki Katsumi, Tomoko Iehara, Yasumichi Kuwahara, Kunihiko Tsuchiya, Eiichi Konishi, Hajime Hosoi. Diverse outcomes in extra-cranial rhabdoid tumors: A single institute experience. Pediatric hematology and oncology. 2022 Apr;39(3):278-285

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PMID: 34668815

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