Enolase 1, a Moonlighting Protein, as a Potential Target for Cancer Treatment.

Gan Qiao, Anguo Wu, Xiaoliang Chen, Ye Tian, Xiukun Lin

International journal of biological sciences 2021

filter terms:

Enolase 1 (ENO1) is a moonlighting protein, function as a glycolysis enzyme, a plasminogen receptor and a DNA binding protein. ENO1 play an important role in the process of cancer development. The transcription, translation, post-translational modifying activities and the immunoregulatory role of ENO1 at the cancer development is receiving increasing attention. Some function model studies have shown that ENO1 is a potential target for cancer treatment. In this review, we provide a comprehensive overview of the characterization, function, related transduction cascades of ENO1 and its roles in the pathophysiology of cancers, which is a consequence of ENO1 signaling dysregulation. And the development of novels anticancer agents that targets ENO1 may provide a more attractive option for the treatment of cancers. The data of sarcoma and functional cancer models indicates that ENO1 may become a new potential target for anticancer therapy. © The author(s).

Citation

Gan Qiao, Anguo Wu, Xiaoliang Chen, Ye Tian, Xiukun Lin. Enolase 1, a Moonlighting Protein, as a Potential Target for Cancer Treatment. International journal of biological sciences. 2021;17(14):3981-3992