The neuroprotective function of 2-carba-cyclic phosphatidic acid: Implications for tenascin-C via astrocytes in traumatic brain injury.

Mari Nakashima, Mari Gotoh, Kei Hashimoto, Misaki Endo, Kimiko Murakami-Murofushi, Hiroko Ikeshima-Kataoka, Yasunori Miyamoto

Journal of neuroimmunology 2021 Dec 15

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We examined the mechanism how 2-carba-cyclic phosphatidic acid (2ccPA), a lipid mediator, regulates neuronal apoptosis in traumatic brain injury (TBI). First, we found 2ccPA suppressed neuronal apoptosis after the injury, and increased the immunoreactivity of tenascin-C (TN-C), an extracellular matrix protein by 2ccPA in the vicinity of the wound region. 2ccPA increased the mRNA expression levels of Tnc in primary cultured astrocytes, and the conditioned medium of 2ccPA-treated astrocytes suppressed the apoptosis of cortical neurons. The neuroprotective effect of TN-C was abolished by knockdown of TN-C. These results indicate that 2ccPA contributes to neuroprotection via TN-C from astrocytes in TBI. Copyright © 2021 The Authors. Published by Elsevier B.V. All rights reserved.

Citation

Mari Nakashima, Mari Gotoh, Kei Hashimoto, Misaki Endo, Kimiko Murakami-Murofushi, Hiroko Ikeshima-Kataoka, Yasunori Miyamoto. The neuroprotective function of 2-carba-cyclic phosphatidic acid: Implications for tenascin-C via astrocytes in traumatic brain injury. Journal of neuroimmunology. 2021 Dec 15;361:577749