Correlation Engine 2.0
Clear Search sequence regions

  • cancer (4)
  • cell growth (2)
  • help (1)
  • humans (1)
  • metastasis (5)
  • oxygen (9)
  • Sizes of these terms reflect their relevance to your search.

    Tumor metastasis is the leading cause of cancer mortality, often characterized by abnormal cell growth and invasion to distant organs. The cancer invasion due to epithelial to mesenchymal transition is affected by metabolic and oxygen availability in the tumor-associated micro-environment. A precise alteration in oxygen and metabolic signaling between healthy and metastatic cells is a substantial probe for understanding tumor progression and metastasis. Molecular heterogeneity in the tumor microenvironment help to sustain the metastatic cell growth during their survival shift from low to high metabolic-oxygen-rich sites and reinforces the metastatic events. This review highlighted the crucial role of oxygen and metabolites in metastatic progression and exemplified the role of metabolic rewiring and oxygen availability in cancer cell adaptation. Furthermore, we have also addressed potential applications of altered oxygen and metabolic networking with tumor type that could be a signature pattern to assess tumor growth and chemotherapeutics efficacy in managing cancer metastasis.


    Vinod S Bisht, Kuldeep Giri, Deepak Kumar, Kiran Ambatipudi. Oxygen and metabolic reprogramming in the tumor microenvironment influences metastasis homing. Cancer biology & therapy. 2021 Dec 02;22(10-12):493-512

    Expand section icon Mesh Tags

    Expand section icon Substances

    PMID: 34696706

    View Full Text