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In this case report, we describe a very rare case of severe limb ischemia due to an arterial embolus caused by an aneurysm of the oval foramen in a term-born infant that occurred in the first few hours after birth. A newborn male Caucasian patient presented on the maternity ward with ischemia of the right foot. Ischemia was treated with nitroglycerin spray and low-molecular-weight heparin in therapeutic dosage. An aneurysm of the oval foramen was found during postnatal echocardiography screening. This was thought to be the source of an embolus causing limb ischemia. At birth and upon follow-up, no clotting disorders were found. A large part of the right forefoot was ischemic, leading to loss of digits 1, 2, and 3. No significant loss of function was found in the first year of life. Severe limb ischemia can be caused by an embolus arising from an aneurysm of the oval foramen and can be treated with heparin. © 2021. The Author(s).


J J van Vonderen, J M H Keus, J van Schaik, F J Smiers, D J Ten Harkel, E Lopriore. A neonate with spontaneous arterial limb ischemia and an aneurysm of the oval foramen: a case report. Journal of medical case reports. 2021 Oct 25;15(1):536

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PMID: 34696819

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