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Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) are common therapeutic agents for EGFR mutation-positive advanced non-small-cell lung cancer. There has been no report of rhabdomyolysis caused by an overdose of EGFR-TKIs. We herein review the existing literature on the subject and report a rare case of rhabdomyolysis due to an overdose of gefitinib, an EGFR-TKI.


Shohei Obayashi, Katsuyoshi Tomomatsu, Mika Urata, Jun Tanaka, Kyoko Niimi, Naoki Hayama, Tsuyoshi Oguma, Koichiro Asano, Yoko Ito. Rhabdomyolysis Caused by Gefitinib Overdose. Internal medicine (Tokyo, Japan). 2022 May 15;61(10):1577-1580

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PMID: 34707044

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