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A 71-year-old female with type B3 thymoma developed severe aplastic anemia. Anti-thymocyte globulin was administered with glucocorticoids and cyclosporin A as the treatment for aplastic anemia. Computed tomography scan revealed that thymoma apparently shrank and remained without regrowth for at least 7 months. As previously reported, glucocorticoid has therapeutic effects on thymoma especially with abundant lymphocytes. Anti-thymocyte globulin also depletes peripheral lymphocytes, but its efficacy in the treatment of thymoma is unknown. Anti-thymocyte globulin and glucocorticoids may have cooperated with each other in reducing thymoma in our case. More cases should be accumulated to elucidate the effects of anti-thymocyte globulin on thymoma. © 2021. The Japanese Association for Thoracic Surgery.


Hiroki Hayashida, Akira Honda, Toshiya Hino, Hideaki Mizuno, Kazuhiro Toyama, Mineo Kurokawa. A case of thymoma showing significant tumor reduction after anti-thymocyte globulin. General thoracic and cardiovascular surgery. 2022 Jan;70(1):96-99

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PMID: 34709554

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