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    A clamp-like triplex switch (CTS) able to simultaneously downregulate an overexpressed onco-miRNA and replenish the lost tumor-suppressive miRNA in a controllable manner was developed for enhanced gene therapy. Compared to the "unidirectional" regulation approach, the CTS displayed improved anti-tumor efficacy in vitro and was harmless to healthy cells.


    Lihua Zhang, Zhen Zou, Yanli Lei, Zhihe Qing, Yu Zeng, Haiyan Sun, Feng Feng, Ronghua Yang. Bidirectional modulation of microRNA with a clamp-like triplex switch for enhanced and programmed gene therapy. Chemical communications (Cambridge, England). 2021 Nov 16;57(91):12131-12134

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    PMID: 34723302

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