A Case of Cefepime-Induced Immune Thrombocytopenia.

Rebecca Bystrom, Minkey Wungwattana, Vatche Tchekmedyian

Journal of clinical pharmacy and therapeutics 2022 Apr

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Drug-induced immune thrombocytopenia (DITP) is a rare adverse event. It is often diagnosed using clinical risk criteria, but this can create diagnostic uncertainty. A 35-year-old man with disseminated Serratia marcescens infection developed severe thrombocytopenia. A drug-dependent platelet-reactive antibody test demonstrated cefepime-dependent platelet-reactive antibodies which confirmed the diagnosis of DITP. We describe the first case of cefepime-induced DITP confirmed by a drug-dependent platelet-reactive antibody test. To our knowledge, this is the first proven example of DITP in a fourth-generation cephalosporin. © 2021 John Wiley & Sons Ltd.

Citation

Rebecca Bystrom, Minkey Wungwattana, Vatche Tchekmedyian. A Case of Cefepime-Induced Immune Thrombocytopenia. Journal of clinical pharmacy and therapeutics. 2022 Apr;47(4):556-558