Tuning curvature and phase behavior of monoolein bilayers by epigallocatechin-3-gallate: Structural insight and cytotoxicity.

Cristina Minnelli, Paolo Moretti, Emiliano Laudadio, Yuri Gerelli, Andrea Pigozzo, Tatiana Armeni, Roberta Galeazzi, Paolo Mariani, Giovanna Mobbili

Colloids and surfaces. B, Biointerfaces 2022 Jan

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The use of glyceryl monooleate (GMO)-based nanoparticles has not yet been explored in overcoming the low bioavailability of Epigallocatechin-3-gallate (EGCG), a green tea polyphenol with a known anticancer activity. Since the inclusion of a guest molecule can affect the curvature and the supramolecular structure of fully hydrated GMO-based phase, the phase behavior of bulk and dispersed liquid crystalline systems containing EGCG were explored by Small Angle Neutron Scattering and X-Ray Diffraction experiments. Molecular Dynamic Simulations showed how the interaction of EGCG with polar heads of GMO strongly affects the curvature and packing of GMO phase. The EGCG encapsulation efficiency was determined in the nanodispersions and their size studied by Dynamic Light Scattering and Atomic Force Microscopy. A nanodispersed formulation has been optimized with a cytotoxic effect more than additive of GMO and EGCG. Copyright © 2021 Elsevier B.V. All rights reserved.

Citation

Cristina Minnelli, Paolo Moretti, Emiliano Laudadio, Yuri Gerelli, Andrea Pigozzo, Tatiana Armeni, Roberta Galeazzi, Paolo Mariani, Giovanna Mobbili. Tuning curvature and phase behavior of monoolein bilayers by epigallocatechin-3-gallate: Structural insight and cytotoxicity. Colloids and surfaces. B, Biointerfaces. 2022 Jan;209(Pt 1):112171