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    To determine if occupational exposure to dioxins is associated with an increased frequency of t(14;18) translocations. A cross-sectional analysis of serum dioxin levels and t(14;18) frequencies in peripheral blood mononuclear cells in 218 former chemical plant workers and 150 population controls. The workers had significantly higher geometric mean serum levels of 2,3,7,8-TCDD (26.2 vs 2.5 ppt) and TEQ (73.8 vs 17.7 ppt) than controls. There were no significant differences in the prevalence or frequency of t(14;18) translocations in the workers compared to controls. Among former workers with current or past chloracne who were t(14;18) positive, the frequency of translocations significantly increased with quartiles of 2,3,7,8-TCDD and TEQ. Chloracne appears to modulate the association between dioxin exposure and increased frequency of t(14;18) translocations. Copyright © 2022 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American College of Occupational and Environmental Medicine.

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    Daniel Hryhorczuk, Irina Dardynskaia, Carsten Hirt, Oleg Dardynskiy, Wayman Turner, Peter Ruestow, Scott Bartell, Kyle Steenland, Oleksandr Zvinchuk, Andrea A Baccarelli. t(14;18) Translocations in Dioxin-Exposed Workers. Journal of occupational and environmental medicine. 2022 Apr 01;64(4):331-339

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    PMID: 34740219

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