t(14;18) Translocations in Dioxin-Exposed Workers.

To determine if occupational exposure to dioxins is associated with an increased frequency of t(14;18) translocations. A cross-sectional analysis of serum dioxin levels and t(14;18) frequencies in peripheral blood mononuclear cells in 218 former chemical plant workers and 150 population controls. The workers had significantly higher geometric mean serum levels of 2,3,7,8-TCDD (26.2 vs 2.5 ppt) and TEQ (73.8 vs 17.7 ppt) than controls. There were no significant differences in the prevalence or frequency of t(14;18) translocations in the workers compared to controls. Among former workers with current or past chloracne who were t(14;18) positive, the frequency of translocations significantly increased with quartiles of 2,3,7,8-TCDD and TEQ. Chloracne appears to modulate the association between dioxin exposure and increased frequency of t(14;18) translocations. Copyright © 2022 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American College of Occupational and Environmental Medicine.

Citation

Daniel Hryhorczuk, Irina Dardynskaia, Carsten Hirt, Oleg Dardynskiy, Wayman Turner, Peter Ruestow, Scott Bartell, Kyle Steenland, Oleksandr Zvinchuk, Andrea A Baccarelli. t(14;18) Translocations in Dioxin-Exposed Workers. Journal of occupational and environmental medicine. 2022 Apr 01;64(4):331-339

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PMID: 34740219

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