Ribosome dysfunction in osteoarthritis.

Guus G H van den Akker, Marjolein M J Caron, Mandy J Peffers, Tim J M Welting

Current opinion in rheumatology 2022 Jan 01

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Translation of genetic information encoded within mRNA molecules by ribosomes into proteins is a key part of the central dogma of molecular biology. Despite the central position of the ribosome in the translation of proteins, and considering the major proteomic changes that occur in the joint during osteoarthritis development and progression, the ribosome has received very limited attention as driver of osteoarthritis pathogenesis. We provide an overview of the limited literature regarding this developing topic for the osteoarthritis field. Recent key findings that connect ribosome biogenesis and activity with osteoarthritis include: ribosomal RNA transcription, processing and maturation, ribosomal protein expression, protein translation capacity and preferential translation. The ribosome as the central cellular protein synthesis hub is largely neglected in osteoarthritis research. Findings included in this review reveal that in osteoarthritis, ribosome aberrations have been found from early-stage ribosome biogenesis, through ribosome build-up and maturation, up to preferential translation. Classically, osteoarthritis has been explained as an imbalance between joint tissue anabolism and catabolism. We postulate that osteoarthritis can be interpreted as an acquired ribosomopathy. This hypothesis fine-tunes the dogmatic anabolism/katabolism point-of-view, and may provide novel molecular opportunities for the development of osteoarthritis disease-modifying treatments. Copyright © 2021 The Author(s). Published by Wolters Kluwer Health, Inc.

Citation

Guus G H van den Akker, Marjolein M J Caron, Mandy J Peffers, Tim J M Welting. Ribosome dysfunction in osteoarthritis. Current opinion in rheumatology. 2022 Jan 01;34(1):61-67