Nef-specific CD107a+ CD4+ T-cell responses in a rhesus macaque (Macaca mulatta) showing partial simian immunodeficiency virus control following passive neutralizing antibody infusion.

Trang Thi Thu Hau, Yoshiaki Kanno, Masako Nishizawa, Takushi Nomura, Tetsuro Matano, Hiroyuki Yamamoto

Journal of medical primatology 2022 Feb

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Acute-phase neutralizing antibody (NAb) passive immunization in simian immunodeficiency virus (SIV)-infected rhesus macaques (Macaca mulatta) can confer stringent viremia control with T-cell augmentation. In one NAb-infused SIV partial controller, we identify chronic-phase Nef-specific CD107a+ CD4+ T-cell response maintenance, implicating that NAb infusion modulates long-term T-cell responses even within viremic control. © 2021 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Citation

Trang Thi Thu Hau, Yoshiaki Kanno, Masako Nishizawa, Takushi Nomura, Tetsuro Matano, Hiroyuki Yamamoto. Nef-specific CD107a+ CD4+ T-cell responses in a rhesus macaque (Macaca mulatta) showing partial simian immunodeficiency virus control following passive neutralizing antibody infusion. Journal of medical primatology. 2022 Feb;51(1):56-61