Muscle-derived factors influencing bone metabolism.

Kevin J Gries, Victoria S Zysik, Tyler K Jobe, Nicole Griffin, Benjamin P Leeds, Jonathan W Lowery

Seminars in cell & developmental biology 2022 Mar

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A significant amount of attention has been brought to the endocrine-like function of skeletal muscle on various tissues, particularly with bone. Several lines of investigation indicate that the physiology of both bone and muscle systems may be regulated by a given stimulus, such as exercise, aging, and inactivity. Moreover, emerging evidence indicates that bone is heavily influenced by soluble factors derived from skeletal muscle (i.e., muscle-to-bone communication). The purpose of this review is to discuss the regulation of bone remodeling (formation and/or resorption) through skeletal muscle-derived cytokines (hereafter myokines) including the anti-inflammatory cytokine METRNL and pro-inflammatory cytokines (e.g., TNF-α, IL-6, FGF-2 and others). Our goal is to highlight possible therapeutic opportunities to improve muscle and bone health in aging. Copyright © 2021 Elsevier Ltd. All rights reserved.

Citation

Kevin J Gries, Victoria S Zysik, Tyler K Jobe, Nicole Griffin, Benjamin P Leeds, Jonathan W Lowery. Muscle-derived factors influencing bone metabolism. Seminars in cell & developmental biology. 2022 Mar;123:57-63