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    Vascular thiol isomerases (VTIs), including PDI, ERp5, ERp57, ERp72, and thioredoxin-related transmembrane protein 1 (TMX1), have important roles in platelet aggregation and thrombosis. Research on VTIs, their substrates in thrombosis, their regulatory mechanisms, and inhibitor development is an emerging and rapidly evolving area in vascular biology. Here, we describe the structures and functions of VTIs, summarize the relationship between the vascular TIs and thrombosis, and focus on the development of VTI inhibitors for antithrombotic applications. Copyright © 2021 Elsevier Ltd. All rights reserved.

    Citation

    Chenghui Liang, Robert Flaumenhaft, Cai Yuan, Mingdong Huang. Vascular thiol isomerases: Structures, regulatory mechanisms, and inhibitor development. Drug discovery today. 2022 Feb;27(2):626-635

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    PMID: 34757205

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