Ortho C-H Functionalization of 2-Arylimidazo[1,2-a]pyridines.

C-H activation and functionalization is quite promising in recent days as the strategy offers a go-to general method for different bond formations and hence grants synthetic versatility. At the same time, imidazopyridine, a fused bicycle of imidazole moiety with pyridine ring, has a profound impact due to its ubiquitous and prodigious application in medicinal as well as material chemistry. The presence of N-1 atom in 2-arylImidazo[1,2-a]pyridine facilitates the coordination with metal catalysts leading to the formation of ortho-substituted products. This review summarizes all the articles on ortho C-H functionalization of 2-arylImidazo[1,2-a]pyridines published till August 2021. © 2021 The Chemical Society of Japan & Wiley-VCH GmbH.

Citation

Sumit Ghosh, Sudip Laru, Alakananda Hajra. Ortho C-H Functionalization of 2-Arylimidazo[1,2-a]pyridines. Chemical record (New York, N.Y.). 2022 Mar;22(3):e202100240

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PMID: 34757691

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