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    Congenital pouch colon is an uncommon anomaly worldwide and is usually associated with anorectal malformations. Imperforate anus with a large air fluid level on the abdominal x ray suggests the diagnosis. Most cases are diagnosed in neonates and an early management limit complications. Few studies have documented the histopathological features of congenital pouch colon. We present two cases with varied associated anomalies (Case 1 with rectovesical fistula, Case 2 with Mayer Rokitansky Kuster Hauser syndrome) and their histopathological features. Immunohistochemistry for calretinin showed paucity of ganglion cells and intrinsic fibers with occasional punctate positivity. The c-Kit immunostain documented fewer interstitial cells of Cajal. Cystitis glandularis with intestinal metaplasia (Case 1) and an additional muscle layer (Case 2) are described. These novel histopathological features characterize the entity further and may be related to genesis of the pouch and its clinical manifestations.


    Neha Singh, Suravi Mohanty, Inchara Yeliur Kalegowda, Pritilata Rout. Congenital Pouch Colon: Further Histopathological Perspectives. Fetal and pediatric pathology. 2022 Oct;41(5):881-888

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    PMID: 34766541

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