Correlation Engine 2.0
Clear Search sequence regions


Sizes of these terms reflect their relevance to your search.

Immunoglobulin E (IgE) is thought to have evolved to protect mammalian hosts against parasitic infections or toxins and plays a central role in the pathogenesis, diagnosis, and therapy of IgE-mediated allergy. Despite the prominence of IgE responses in most parasitic infections, and in stark contrast to its use in the diagnosis of allergy, this isotype is almost completely unexploited for parasite diagnosis. Here, we discuss the perceived or real limitations of IgE-based diagnosis in parasitology and suggest that the recent creation of a new generation of very sensitive cellular IgE-based reporters may represent a powerful new diagnostic platform, but needs to be based on a very careful choice of diagnostic allergens. © 2021. The Author(s).

Citation

Prema S Prakash, Michael H W Weber, Jaap J van Hellemond, Franco H Falcone. Are humanized IgE reporter systems potential game changers in serological diagnosis of human parasitic infection? Parasitology research. 2022 Apr;121(4):1137-1144

Expand section icon Mesh Tags

Expand section icon Substances


PMID: 34767081

View Full Text