Correlation Engine 2.0
Clear Search sequence regions


  • brain (2)
  • cellular (1)
  • humans (1)
  • isozymes (4)
  • target genes (1)
  • Sizes of these terms reflect their relevance to your search.

    Genetic mutations leading to the development of various diseases, such as cancer, diabetes, and neurodegenerative disorders, can be attributed to multiple mechanisms and exposure to diverse environments. These disorders further increase gene mutation rates and affect the activity of translated proteins, both phenomena associated with cellular responses. Therefore, maintaining the integrity of genetic and epigenetic information is critical for disease suppression and prevention. With the advent of genome sequencing technologies, large-scale genomic data-based machine learning tools, including deep learning, have been used to predict and identify somatic inactivation or negative dominant expression of target genes in various diseases. Although deep learning studies have recently been highlighted for their ability to distinguish between the genetic information of diseases, conventional wisdom is also necessary to explain the correlation between genotype and phenotype. Herein, we summarize the current understanding of phosphoinositide-specific phospholipase C isozymes (PLCs) and an overview of their associations with genetic variation, as well as their emerging roles in several diseases. We also predicted and discussed new findings of cryptic PLC splice variants by deep learning and the clinical implications of the PLC genetic variations predicted using these tools. Copyright © 2021 The Authors. Published by Elsevier Ltd.. All rights reserved.

    Citation

    Jae-Yeol Joo, Key-Hwan Lim, Sumin Yang, Sung-Hyun Kim, Lucio Cocco, Pann-Ghill Suh. Prediction of genetic alteration of phospholipase C isozymes in brain disorders: Studies with deep learning. Advances in biological regulation. 2021 Dec;82:100833

    Expand section icon Mesh Tags

    Expand section icon Substances


    PMID: 34773889

    View Full Text