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This study seeks to discover how the concentration of complement proteins, factors B and P are affected in HIV-associated PE. This study included 72 pregnant women: 36 preeclamptic and 36 normotensive. Serum concentrations of factors B and P were measured using a Bioplex immunoassay. A significant decrease of factor B in the HIV+ compared to the HIV- group was noted. No significant difference across all groups for both analytes was observed. Our results suggest the alternative pathway (AP) is inhibited by HIV evading immune detection. The AP is not excessively activated in PE during the third trimester.


Phumelele Kikine, Yazira Pillay, Thajasvarie Naicker. THE ROLE OF HUMAN COMPLEMENT PROTEIN FACTOR B AND FACTORP/PROPERDIN IN HIV-ASSOCIATED PRE-ECLAMPSIA. Hypertension in pregnancy. 2022 Feb;41(1):9-14

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PMID: 34781830

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