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In this article, members of the American College of Radiology Committee on Drugs and Contrast Media propose a new term for symptoms reported after intravascular exposure to gadolinium-based contrast agents-Symptoms Associated with Gadolinium Exposure, or SAGE. This term is advocated in lieu of other proposed nomenclature that presumes a causal relationship that has not yet been scientifically verified. The purpose of this new term, SAGE, is to assist researchers and clinical providers in describing such symptoms without prematurely causally attributing them to a disease and to standardize reporting of these symptoms to allow for coherent interpretation of related studies. © RSNA, 2021.


Robert J McDonald, Jeffrey C Weinreb, Matthew S Davenport. Symptoms Associated with Gadolinium Exposure (SAGE): A Suggested Term. Radiology. 2022 Feb;302(2):270-273

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PMID: 34783590

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