The immunologic balance: three cases of rituximab-associated melanoma.

Currently, there is no known clinical evidence that rituximab increases the rate of subsequent primary malignancies; however, some studies have raised the question of increased melanoma risk following rituximab treatment for non-Hodgkin lymphoma. We report three interesting cases of suspected rituximab-induced melanoma. We hypothesize that this association is secondary to rituximab-driven shifts in the immunologic balance. Based on these cases, it is possible that the number of post-rituximab melanoma cases is underreported. Further mechanistic research into individual cases and population-level studies are required to better define association and risk; however, given the increasing prevalence of oncologic and nononcologic rituximab use, awareness across all fields is essential. Copyright © 2021 Wolters Kluwer Health, Inc. All rights reserved.

Citation

Tara M Davidson, Svetomir N Markovic, Anastasios Dimou. The immunologic balance: three cases of rituximab-associated melanoma. Melanoma research. 2022 Feb 01;32(1):67-70

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PMID: 34783721

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