Rapid improvement of skin lesions in CHILD syndrome with topical 5% simvastatin ointment.

Penelope Kallis, Elizabeth Bisbee, Cheryl Garganta, Jennifer J Schoch

Pediatric dermatology 2022 Jan

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Congenital hemidysplasia with ichthyosiform erythroderma and limb defects (CHILD) syndrome is a rare X-linked dominant disorder of cholesterol synthesis characterized by unilateral ichthyosiform dermatitis with ipsilateral limb hypoplasia. Recently, pathogenesis-based treatment has demonstrated improvement of skin lesions with statins by decreasing formation of cholesterol intermediates through inhibition of cholesterol synthesis. We report a 10-month-old girl who presented with unilateral scaly ptychotropic plaques, who experienced rapid, near-complete clearance with topical 5% simvastatin monotherapy twice daily. © 2021 Wiley Periodicals LLC.

Citation

Penelope Kallis, Elizabeth Bisbee, Cheryl Garganta, Jennifer J Schoch. Rapid improvement of skin lesions in CHILD syndrome with topical 5% simvastatin ointment. Pediatric dermatology. 2022 Jan;39(1):151-152