The effect of cytoplasmic dynein on the development and functional maintenance of retinal photoreceptor cells.

B Jia, C-G Wang, H Chen, X-B Zhou, K Qian, C Chen, L-X Xu, J-L Fu

European review for medical and pharmacological sciences 2021 Nov

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Cytoplasmic dynein is a multi-subunit complex that includes cytoplasmic dynein-1 (dynein1) and cytoplasmic dynein-2 (dynein2). It participates in various basic cellular processes, including nuclear migration, mitotic spindle organization, chromosome separation during mitosis, and the location and function of numerous intracellular organelles. Retinal photoreceptor cells are terminally differentiated neurons that cannot regenerate and cannot be replaced once lost. It is thus crucial to study their development to facilitate the generation and improvement of photoreceptor disease treatments. The outer segment (OS) of photoreceptor cells is a specific sensory cilium. An increasing number of studies have shown that cytoplasmic dynein plays an essential role in the development of retinal photoreceptor cells. To date, people have done a lot of studies on the various functions of dynein in cells and have a very detailed understanding. However, the role of dynein in retinal photoreceptor cells has not been summarized in detail. This article summarizes the currently available knowledge relating to the effects and mechanisms of cytoplasmic dynein on the development and functional maintenance of retinal photoreceptor cells.

Citation

B Jia, C-G Wang, H Chen, X-B Zhou, K Qian, C Chen, L-X Xu, J-L Fu. The effect of cytoplasmic dynein on the development and functional maintenance of retinal photoreceptor cells. European review for medical and pharmacological sciences. 2021 Nov;25(21):6539-6547