Understanding how kinesin motor proteins regulate postsynaptic function in neuron.

Ruolin Fan, Kwok-On Lai

The FEBS journal 2022 Apr

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The Kinesin superfamily proteins (KIFs) are major molecular motors that transport diverse set of cargoes along microtubules to both the axon and dendrite of a neuron. Much of our knowledge about kinesin function is obtained from studies on axonal transport. Emerging evidence reveals how specific kinesin motor proteins carry cargoes to dendrites, including proteins, mRNAs and organelles that are crucial for synapse development and plasticity. In this review, we will summarize the major kinesin motors and their associated cargoes that have been characterized to regulate postsynaptic function in neuron. We will also discuss how specific kinesins are selectively involved in the development of excitatory and inhibitory postsynaptic compartments, their regulation by post-translational modifications (PTM), as well as their roles beyond conventional transport carrier. © 2021 Federation of European Biochemical Societies.

Citation

Ruolin Fan, Kwok-On Lai. Understanding how kinesin motor proteins regulate postsynaptic function in neuron. The FEBS journal. 2022 Apr;289(8):2128-2144