The effects of choreito on a model of nocturnal polyuria using Dahl salt-sensitive rats.

This study aimed to determine whether Dahl salt-sensitive rats fed a high-salt diet would show features of nocturia due to nocturnal polyuria and to examine the efficacy of choreito (CRT) on nocturnal polyuria. Dahl salt-sensitive rats were divided into three groups. Group A was fed a 4% salt diet, group B a 2% salt diet, and group C a normal 0.3% salt diet. In groups α and β, other rats were further divided into two groups: The rats in group α were fed a 2% salt plus 3% CRT diet, and those in group β, were fed a 2% salt diet. Each rat was placed in an individual metabolic cage for 24 hours every week for 6 weeks. Water intake, urine production, voiding frequency, and voided volume per micturition were recorded. The systolic blood pressure increased in the group fed a 4% salt diet compared to groups fed with a 2% and 0.3% salt diet. The urinary volume was higher in the groups fed with 4% and 2% salt than in the group fed with 0.3% salt. Further, water intake in the group fed a 2% salt plus 3% CRT diet was significantly lower than that in the group fed with a 2% salt diet. Dahl salt-sensitive rats fed a 2% salt diet were candidates for a model of nocturnal polyuria. Using this model, we suggest that CRT reduces water intake in the active phase and contributes to water restriction in the treatment of nocturnal polyuria. © 2021 John Wiley & Sons Australia, Ltd.

Citation

Takashi Iwamoto, Kazumasa Torimoto, Daisuke Gotoh, Shunta Hori, Yasushi Nakai, Makito Miyake, Yohei Tokita, Ryohei Kobayashi, Katsuya Aoki, Kiyohide Fujimoto. The effects of choreito on a model of nocturnal polyuria using Dahl salt-sensitive rats. Lower urinary tract symptoms. 2022 Mar;14(2):122-128

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PMID: 34796672

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