Evaluation of dynamic thiol-disulfide balance in preinvasive lesions of the cervix.

Burak Sezgin, Fatih Pirinççi, Aysun Camuzcuoğlu, E Adeviye Şahin, Özcan Erel, Salim Neşelioğlu, Hakan Camuzcuoğlu

Archives of gynecology and obstetrics 2022 Mar

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This study aimed to determine the potential clinical use of dynamic thiol-disulfide balance in cases with preinvasive lesions of the cervix. One hundred and sixteen patients with high-grade squamous intraepithelial lesion, 100 patients with low-grade squamous intraepithelial lesion, and 110 healthy controls were enrolled in the study. A fully automated colorimetric system was used to determine the levels of thiol-disulfide parameters. The ischemia-modified albumin, total oxidant-antioxidant capacity, and oxidative stress index of the retrieved cases were further analyzed. Native thiol and total thiol levels are significantly lower in the high-grade squamous intraepithelial lesion group according to control group (p: 0.004 and 0.015, respectively). Disulfide level is significantly increased in the high-grade squamous intraepithelial lesion group compared to control group (p: 0.004). Oxidative stress index levels in high-grade squamous intraepithelial lesion group were observed as significantly higher according to the control group (p: 0.014). Ischemia-modified albumin levels in the high-grade squamous intraepithelial lesion group were observed as significantly higher compared to the control group (p: 0.020). Disulfide levels are positively correlated with risk type of Human papillomavirus (r: 0.420, p < 0.001). The analysis of dynamic thiol-disulfide balance revealed considerable oxidative damage in patients with Human papillomavirus-related cervical precursor lesions compared to women with ordinary cytology specimens. Therefore, investigation of thiol-disulfide balance with presented method represents a new promising test for early diagnosis and management of women at high risk for cervical cancer. © 2021. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.

Citation

Burak Sezgin, Fatih Pirinççi, Aysun Camuzcuoğlu, E Adeviye Şahin, Özcan Erel, Salim Neşelioğlu, Hakan Camuzcuoğlu. Evaluation of dynamic thiol-disulfide balance in preinvasive lesions of the cervix. Archives of gynecology and obstetrics. 2022 Mar;305(3):617-623