Correlation Engine 2.0
Clear Search sequence regions


Sizes of these terms reflect their relevance to your search.

To make full use of the porcine sources and develop better choice of novel GAGs as anti-coagulants, two fractions of GAGs from the porcine jejunum (A) and duodenum (C) have been separated & purified. The products were further sulfated to give B and D in order to test the influence of sulfate pattern on the bioactivity. The results showed that the relative molecular weight range of A was 3000-50,000 (Mw, g/mol), whereas C had an average molecular weight of 75,885 (Mw, g/mol). A was identified as a novel heparan sulfate through enzymatic hydrolysis analysis. C was a chondroitin like polysaccharide mainly composed of β-d-GlcA-(1 → 4) and β-d-GalNAc-(1 → 3). A possessed controllable anti-coagulant activity (7 IU/mg) in vitro. The activity of D almost achieved the same magnitude of A. This study demonstrated the anticoagulant potential of the polysaccharides, providing solid foundation for development of anti-coagulants from porcine intestine. Copyright © 2021 Elsevier Ltd. All rights reserved.

Citation

Yishu Yan, Panpan Ren, Qingqing Wu, Xiaoni Liu, Zhenqing Zhang, Minyu Hua, Wei Xia, Jinghua Chen. Structure comparison and anti-coagulant effects of the glycosaminoglycans from porcine duodenum and jejunum. Food chemistry. 2022 Mar 30;373(Pt B):131609

Expand section icon Mesh Tags

Expand section icon Substances


PMID: 34819245

View Full Text