New dihydronaphthothiophene derivatives by the biological transformation of seriniquinone using marine-derived actinomycete Streptomyces albogriseolus OM27-12.

Kohei Ishida, Teruki Tanaka, Kenichiro Nagai, Yoshimasa Furuichi, Takeshi Terahara, Masashi Ando, Yasuyuki Tsukamasa, Takashi Fukuda

The Journal of antibiotics 2022 Jan

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Seriniquinone was originally isolated as a melanoma-selective anti-cancer agent from a culture broth of marine bacteria. Pharmacological studies on its selectivity and unique target are ongoing. A new dihydronaphthothiophene (1) was synthesized by the biological transformation of seriniquinone using marine-derived actinomycete Streptomyces albogriseolus OM27-12, and its derivatives (2-4) were chemically synthesized. Compounds 1-4 exhibited selective cytotoxic activity against melanoma and improved solubility. © 2021. The Author(s), under exclusive licence to the Japan Antibiotics Research Association.

Citation

Kohei Ishida, Teruki Tanaka, Kenichiro Nagai, Yoshimasa Furuichi, Takeshi Terahara, Masashi Ando, Yasuyuki Tsukamasa, Takashi Fukuda. New dihydronaphthothiophene derivatives by the biological transformation of seriniquinone using marine-derived actinomycete Streptomyces albogriseolus OM27-12. The Journal of antibiotics. 2022 Jan;75(1):9-15