Improved separation scheme for 44Sc produced by irradiation of natCa targets with 12.8 MeV protons.

44Sc is of great interest as a positron emission tomography (PET) radionuclide due to its suitable nuclear characteristics: Eβ+max = 1.47 MeV, branching ratio 94.3% and convenient half-life of 3.97 h. Here, 44Sc was produced via the widely used reaction 44Ca (p,n)44Sc using natural calcium as a target. The irradiation was performed at TRIUMF using the 13 MeV cyclotron. The separation consisted of a combination of DGA branched resin and Dowex 50Wx8 (200-400 mesh). The distribution coefficients of Sc3+ on Dowex 50Wx8 (NH4+ form, 200-400 mesh) with ammonium α-hydroxyisobutyrate (pH = 4.8) medium were determined in this study. The tested scheme allows both a reliable separation of 44Sc from the target material as well as from the other competitive metals and a final fraction with high specific activity. The achieved radiochemical yield was 95 ± 3%. Copyright © 2021 Elsevier Inc. All rights reserved.

Citation

E S Kurakina, L Wharton, C Hoehr, C Orvig, E P Magomedbekov, D Filosofov, V Radchenko. Improved separation scheme for 44Sc produced by irradiation of natCa targets with 12.8 MeV protons. Nuclear medicine and biology. 2022 Jan-Feb;104-105:22-27

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PMID: 34847480

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