Plant hvu-MIR168-3p enhances expression of glucose transporter 1 (SLC2A1) in human cells by silencing genes related to mitochondrial electron transport chain complex I.

Yukihiro Akao, Yuki Kuranaga, Kazuki Heishima, Nobuhiko Sugito, Kohei Morikawa, Yuko Ito, Tomoyoshi Soga, Tomohiro Ito

The Journal of nutritional biochemistry 2022 Mar

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Diet is a crucial factor for preventing most diseases. Edible plant extracts are known to contain exosome-like nanoparticles, in which food-derived plant microRNAs are included and may serve as a novel functional component in human health. Here, we demonstrated that hvu-MIR168-3p included in the nanoparticles of rice aleurone cells down-regulated the expression of the genes related to mitochondrial electron transport chain complex I in human cells. Subsequently, hvu-MIR168-3p enhanced protein and RNA expression levels of glucose transporter I and caused a decrease in the blood glucose level, which findings were obtained by in vitro and in vivo experiments, respectively. These findings suggest that a cross-kingdom relationship between plants and humans with respect to hvu-MIR168-3p exists and may contribute to preventive medicine for GLUT1-related dysfunctions including glucose metabolism, aging, and tumor immunology. Copyright © 2021 The Author(s). Published by Elsevier Inc. All rights reserved.

Citation

Yukihiro Akao, Yuki Kuranaga, Kazuki Heishima, Nobuhiko Sugito, Kohei Morikawa, Yuko Ito, Tomoyoshi Soga, Tomohiro Ito. Plant hvu-MIR168-3p enhances expression of glucose transporter 1 (SLC2A1) in human cells by silencing genes related to mitochondrial electron transport chain complex I. The Journal of nutritional biochemistry. 2022 Mar;101:108922