Uterine Receptivity is Reflected by LIF Expression in the Cervix.

Yamato Fukui, Yasushi Hirota, Shizu Aikawa, Chihiro Ishizawa, Rei Iida, Tetsuaki Kaku, Tomoyuki Hirata, Shun Akaeda, Takehiro Hiraoka, Mitsunori Matsuo, Yutaka Osuga

Reproductive sciences (Thousand Oaks, Calif.) 2022 May

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Recurrent implantation failure is a major problem in assisted reproductive technology (ART). Although ART systems have evolved rapidly over the decades, it is still difficult to diagnose uterine conditions suitable for embryo transfer (ET) without the use of invasive endometrial procedures. Previous studies in mice showed that leukemia inhibitory factor (LIF) is a well-known endometrial biomarker for uterine implantation capacity, also known as uterine receptivity. This study focused on LIF in the mouse and human cervix as a possible biomarker of implantation capacity. We found that high expression of LIF in the cervical epithelium is strongly correlated with that of the uterine epithelium during the peri-implantation period in mice. Likewise, human cervical epithelia also exhibit elevated levels of LIF in the peri-implantation period. In addition, cervical LIF is downregulated in mice with defective implantation caused by pharmacological treatments. These results indicated that cervical LIF is a possible biomarker that detected uterine receptivity without invasive endometrial damage. © 2021. Society for Reproductive Investigation.

Citation

Yamato Fukui, Yasushi Hirota, Shizu Aikawa, Chihiro Ishizawa, Rei Iida, Tetsuaki Kaku, Tomoyuki Hirata, Shun Akaeda, Takehiro Hiraoka, Mitsunori Matsuo, Yutaka Osuga. Uterine Receptivity is Reflected by LIF Expression in the Cervix. Reproductive sciences (Thousand Oaks, Calif.). 2022 May;29(5):1457-1462